General Information

  • ID:  hor005043
  • Uniprot ID:  P82693
  • Protein name:  Pyrokinin-6
  • Gene name:  NA
  • Organism:  Periplaneta americana (American cockroach) (Blatta americana)
  • Family:  pyrokinin family
  • Source:  animal
  • Expression:  Corpora alata and to a lesser extent in abdominal perisympathetic organs.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Periplaneta (genus), Blattinae (subfamily), Blattidae (family), Blattoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SESEVPGMWFGPRL
  • Length:  14(1-14)
  • Propeptide:  SESEVPGMWFGPRL
  • Signal peptide:  NA
  • Modification:  T14 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  in the head of cockroach, Pea鈥怭K鈥? can be released as a neurohormone into the hemolymph;innervate target organs such as pharyngeal dilator muscles and aorta wall via the NCC鈥?
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005043_AF2.pdbhor005043_ESM.pdb

Physical Information

Mass: 182384 Formula: C72H106N18O21S
Absent amino acids: ACDHIKNQTY Common amino acids: EGPS
pI: 4.26 Basic residues: 1
Polar residues: 4 Hydrophobic residues: 4
Hydrophobicity: -37.86 Boman Index: -1684
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 48.57
Instability Index: 5892.86 Extinction Coefficient cystines: 5500
Absorbance 280nm: 423.08

Literature

  • PubMed ID:  10723010
  • Title:  Tagma-specific distribution of FXPRLamides in the nervous system of the American cockroach.